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Virucidal activity of olanexidine gluconate against SARS-CoV-2
Antiseptics have been used for infection control against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ethanol (EtOH) was found to be effective against SARS-CoV-2 while chlorhexidine gluconate (CHG) was less effective. Therefore virucidal activity may differ between different classes of antiseptic agents. In this study the efficacy of antiseptics against SARS-CoV-2 was evaluated and effective agents for infection control were identified. The following antiseptics were used in this study: 1.5% olanexidine gluconate (OLG); 80% EtOH; 1% sodium hypochlorite (NaClO); 0.2% benzalkonium chloride (BKC); 1% povidone-iodine (PVP-I); 0.5% 1% and 1.5% CHG; and 0.5% alkyldiaminoethylglycine hydrochloride (AEG). The virucidal activity was evaluated at 0 0.5 1 2 and 3 min according to EN14476. After 0.5 min of exposure 1.5% OLG 80% EtOH 1% NaClO 0.2% BKC and 1% PVP-I inactivated SARS-CoV-2 below the detection limit. The virus survived in the presence of 0.5% CHG 1% CHG or 0.5% AEG for 3 min. The virucidal activity of 1.5% CHG was insufficient after 0.5 min of exposure. The results showed that virucidal activity against SARS-CoV-2 differs depending on the class of antiseptic agents used under clean conditions. Despite belonging to the same class of biguanide antiseptics OLG was more effective against SARS-CoV-2 than CHG.
Preprint: Virucidal activity of olanexidine gluconate against SARS-CoV-2
Introduction: Antiseptics have been used for infection control against SARS-CoV-2. Ethanol (EtOH) was effective against SARS-CoV-2 while chlorhexidine gluconate (CHG) was less effective. Therefore there may be differences in virucidal activity between classes of antiseptic agents. Aim: In this study we evaluated the efficacy of antiseptics against SARS-CoV-2 and identified effective agents for infection control. Methods: The following antiseptics were used in this study: 1.5% olanexidine gluconate (OLG); 80% EtOH; 1% sodium hypochlorite (NaClO); 0.2% benzalkonium chloride (BKC); 1% povidone-iodine (PVP-I); 0.5% 1% and 1.5% chlorhexidine gluconate (CHG); and 0.5% alkyldiaminoethylglycine hydrochloride (AEG). Virucidal activity was evaluated at 0 30 s 1 2 and 3 min according to EN14476. Results: After 30 s of exposure 1.5% OLG 80% EtOH 1% NaClO 0.2% BKC and 1% PVP-I inactivated SARS-CoV-2 below the detection limit. In contrast the virus was survived in 0.5% CHG 1% CHG and 0.5% AEG after 3 min of exposure. However the virucidal activity of 1.5% CHG was insufficient after 30 s of exposure. Conclusion: This study showed that the virucidal activity against SARS-CoV-2 differs depending on the class of antiseptic agent. Despite belonging to the same class of biguanide antiseptics OLG was more effective against SARS-CoV-2 than CHG.