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Corrigendum: Identification and structural characterisation of a catecholate-type siderophore produced by Stenotrophomonas maltophilia K279a
Idification and structural characterisation of a catecholate-type siderophore produced by Stenotrophomonas maltophilia K279a
Siderophores are produced by several bacteria that utilise iron in various environments. Elucidating the structure of a specific siderophore may have valuable applications in drug development. Stenotrophomonas maltophilia a Gram-negative bacterium that inhabits a wide range of environments and can cause pneumonia produces siderophores. However the structure was unknown and therefore in this study we aimed to elucidate it. We purified siderophores from cultures of S. maltophilia K279a using preparative reversed-phase HPLC. The structure was analysed through LC-MS and 1H and 13C NMR. The results demonstrated that S. maltophilia K279a produces 23-dihydroxybenzoylserine (DHBS) a monomer unit of enterobactin. We suggested the uptake of Iron(III) by the DHBS complex. DHBS production by S. maltophilia K279a could be attributed to an incomplete enterobactin pathway. Drugs targeting DHBS synthesis could prevent S. maltophilia infection.