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Candida

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Candida
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In conjunction with the Candida and Candidiasis meeting, Microbiology Society is bringing together research on Candida biology – species that are major causes of infectious disease in AIDS patients, cancer chemotherapy patients, premature infants, etc. The polymorphic yeast Candida albicans is the most important fungal pathogen in humans. Beyond the clinics, basic research in this organism deals with a variety of topics of interest, like the genetics and molecular biology behind antifungal drug resistance; the molecular determinants of endurance to nutritional, pH and oxidative stress imposed by the host defences; or its interactions with both the host epithelia and bacterial partners that share the mucosal microbiota with the fungus. This collection of research articles published on diverse aspects of Candida biology showcases the journals’ range of Candida research. This collection is open for submissions across our portfolio. Authors are invited to submit on any aspect of Candida research. Upon submission, please indicate that your manuscript is to be considered for the Candida collection.

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    • Genomic epidemiology of human candidaemia isolates in a tertiary hospital

      Invasive candida infections are significant infections that may occur in vulnerable patients with high rates of mortality or morbidity. Drug-resistance rates also appear to be on the rise which further complicate treatment options and outcomes. The aims of this study were to describe the prevalence, molecular epidemiology, and genetic features of bloodstream isolates in a hospital setting. The resistance mechanisms towards the two most commonly administered antifungals, fluconazole and anidulafungin, were determined. Blood culture isolates between 1 January 2018 and 30 June 2021 positive for spp. were included. Susceptibility testing was performed using Etest. Whole-genome-sequencing was performed using Illumina NovaSeq with bioinformatics analysis performed. A total of 203 isolates were sequenced: 56 . 53 . , 44 . 36 . complex (consisting of and ), six . five . , and three . . A single cluster of azole-resistant and four clusters of isolates were observed, suggesting possible transmission occurring over several years. We found 11.3%, and 52.7 % of and , respectively, clustered with other isolates, suggesting exogenous sources may play a significant role of transmission, particularly for . The clusters spanned over several years suggesting the possibility of environmental reservoirs contributing to the spread. Limited clonality was seen for . Several sequence types appeared to be dominant for however the SNP differences varied widely, indicating absence of sustained transmission.

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